Dependence of Higher Frequency Components on Bone Tissue Alterations in the Rat-tail Model

Through a recently conducted rat-tail vibration experiment, we have been able to determine that the tested frequencies of vibration have a significant effect on biochemical damage signified by nitro-tyrosine (NT) staining on trabecular bone, while structural damage quantified through a Hematoxylin and Eosin (H&E) stain on cortical bone exhibited statistical significance only for the 250 Hz group compared to the control group. These results seem to indicate a relationship between the growing quantities of biochemical damage when increasing the excitation frequency, thus further experimentation for frequencies between 250 Hz and 400 Hz is recommended.